Journal article
A tunable one-pot three-component synthesis of an 125I and Gd-labelled star polymer nanoparticle for hybrid imaging with MRI and nuclear medicine
L Esser, NA Lengkeek, BA Moffat, MN Vu, I Greguric, JF Quinn, TP Davis, MR Whittaker
Polymer Chemistry | ROYAL SOC CHEMISTRY | Published : 2018
DOI: 10.1039/c8py00621k
Abstract
The successful treatment of a disease via individualized treatment protocols relies on an early and accurate diagnosis. Advances to imaging hardware, such as hybrid PET/MRI scanners, have overcome the inherit disadvantages associated with the individual imaging modality. However, well-designed multimodal contrast agents are essential to optimally exploit hybrid PET/MRI systems. Herein, we show that core-cross-linked azide-functional star polymer nanoparticles can be simultaneously labelled with a radioisotope (radioiodine) and a clinically-used MRI contrast agent (Gd-DOTA) by exploiting an elegant copper-catalyzed one-pot three-component reaction creating an iodotriazole. The nanoparticles h..
View full abstractGrants
Awarded by Australian Research Council
Funding Acknowledgements
This work was carried out within the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). L. E. would like to thank AINSE Ltd for providing financial assistance (Award - PGRA, ALNGRA14022) to enable work on radiolabelling. T. P. D. is grateful for the award of an Australian Laureate Fellowship from the ARC. J. F. Q. acknowledges receipt of a Future Fellowship from the ARC (FT170100144). Electron Microscopy work was carried out at the Bio21 Advanced Microscopy Facility, The University of Melbourne. Finally, the authors would like to thank Joanne Ly for providing the relaxivity data for Magnevist and Nghia Truong Phuoc for assisting with TEM imaging.